Recent research highlights that psoriasis, a common skin condition affecting approximately 8 million Americans, may be associated with a heightened risk of developing 16 different types of cancer. Published in Nature, the study, led by dermatology and endocrinology experts in China, also identifies a cause-and-effect relationship between psoriasis and specific cancers.
The study analyzed data from 13,463 patients with psoriasis and 463,136 without, utilizing public datasets including the UK Biobank and TCGA data. Psoriasis, characterized by red, itchy patches on various parts of the body, is known for its inflammatory nature and has now been linked to several cancers, including lung, breast, and liver cancers.
Using polygenic risk scores and Mendelian randomization analyses, the researchers explored connections between psoriasis and 89 cancer types. They confirmed associations with cancers of the lung and breast and highlighted genetic differences in psoriasis-related genes in cancer tissues.
The researchers emphasize that while more studies are needed to fully understand the causal mechanisms, their findings suggest a significant hereditary cancer risk for psoriasis patients. They recommend increased clinical vigilance for lung and breast cancers among those with psoriasis.
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