A recent study conducted at the University of Jyväskylä, Finland, reveals that genetic factors contributing to sedentary behavior may significantly elevate the risk of developing common cardiovascular diseases. The study, the first of its kind, shows that individuals with a high genetic predisposition to sedentary behavior could face up to a 20% higher risk of heart-related conditions.
The research, led by the university’s Faculty of Sport and Health Sciences, explored the connection between genetic predispositions to inactivity and cardiovascular health. Using genetic and health data from nearly 330,000 Finns provided by FinnGen, the team developed a polygenic score to measure genetic predisposition to leisure screen time—a common form of voluntary sedentary behavior.
Through this method, the researchers were able to identify the link between genetic tendencies toward sedentary behavior and the increased risk of cardiovascular diseases, including hypertensive conditions, ischemic heart diseases like myocardial infarction, and cerebrovascular diseases. The findings were corroborated by a separate reference group of around 35,000 Norwegians.
Postdoctoral researcher Laura Joensuu, who led the study, explained that individuals with the highest genetic predisposition to sedentary behavior tended to spend an additional 30 minutes per day inactive. This seemingly minor increase in sedentary time was associated with a significant 20% greater risk of developing cardiovascular conditions compared to those with the lowest genetic predisposition.
While sedentary behavior may be an evolutionary trait, with paleoanthropologists suggesting that physical activity may not have evolved as a voluntary human trait, Joensuu stresses the importance of combating these natural inclinations. “Even though the genetic tendency to be sedentary may be ingrained, the benefits of physical activity cannot be overstated,” Joensuu said. “It’s important to push through the natural resistance to exercise, as it plays a crucial role in our overall wellbeing.”
The research underscores the need to promote physical activity as a part of public health strategies. Joensuu advocates for fostering a community-driven approach to exercise that emphasizes enjoyment and social connection.
The study, which was published in the prestigious British Journal of Sports Medicine, was part of the GenActive research group at the University of Jyväskylä. This group, led by Associate Professor Elina Sillanpää, investigates how genetic and lifestyle factors influence health and aging.
The study was funded by multiple organizations, including the Research Council of Finland, the Juho Vainio Foundation, the Päivikki and Sakari Sohlberg Foundation, and the Sigrid Juselius Foundation.
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